Estradici and Progesterone Receptors in Malignant Gastrointestinal Tumors1
نویسندگان
چکیده
Estradici and progesterone receptors were assayed in tumors from 79 patients with primary colorectal and 56 patients with stomach adenocarcinomas. Eighteen of 79 colorectal cancers contained estradiol receptor, while 34 specimens were positive for progesterone receptor. In stomach cancer, the positive sam ples were 8 for estradiol and 14 for progesterone receptors. In both types of tumors, the Kd was in the range of 10~10 M for estradiol and 10~9 M for progesterone receptor, respectively. In colorectal adenocarcinomas, the presence of progesterone re ceptor seems to be partially correlated to the presence of estra diol receptor while, in stomach tumors, this correlation is lost. The positivity of at least one receptor in colorectal cancers is higher in the female sex. The contrary occurs for stomach cancer. Sucrose gradient centrifugation showed that cytoplasmic estra diol receptor of stomach cancer sedimented at 8S or 4 to 5S at low ionic strength. The isoelectric point of stomach cancer estradiol receptor is 6.5.
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